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Pandemic preparednessBlog 1 · Clinical evidence20 Oct 20264 min read

HemoClear convalescent plasma associated with reduced mortality in COVID-19 ICU patients

Lessons from Suriname: making antibody-based treatment accessible during a pandemic

Gloved hand holding blood sample tubes in a rack

During the COVID-19 pandemic, hospitals worldwide faced unprecedented pressure. In Suriname, limited access to conventional plasmapheresis equipment created an additional challenge: how could clinicians obtain convalescent plasma from recovered patients when specialized collection systems were unavailable?

HemoClear provided a practical solution.

A clinical study involving 200 ICU patients

Researchers at the Academic Hospital Paramaribo investigated HemoClear-produced COVID-19 convalescent plasma in patients with severe SARS-CoV-2 infection.

Among 200 ICU patients, 58 received convalescent plasma in addition to standard care, while 142 received standard care alone.

The observed mortality was:

  • 21% in patients receiving convalescent plasma.
  • 39% in patients receiving standard care alone.

The study reported a statistically significant association between plasma treatment and lower mortality, with an adjusted hazard ratio of 0.35.

A promising finding with important limitations

These results were encouraging, particularly in a resource-constrained healthcare environment. However, this was a nonrandomized study, meaning that differences between patient groups could have influenced the outcome.

The results therefore support further investigation rather than proving treatment efficacy.

Implications for pandemic preparedness

The Suriname experience demonstrated that hospitals without conventional plasmapheresis machines could produce convalescent plasma locally using HemoClear.

This capability may be valuable during future outbreaks when access to specialized blood-processing infrastructure is limited.

Quote from the publication
"Bedside plasma separation using the HemoClear device made convalescent plasma therapy accessible as a treatment option in Suriname."

Scientific reference

Bihariesingh-Sanchit R, Bansie R, Ramdhani N, et al. Reduced Mortality among COVID-19 ICU Patients after Treatment with HemoClear Convalescent Plasma in Suriname. mBio. 2023;14(2).
DOI: 10.1128/mbio.03379-22
HemoClear takeaway: Local production of convalescent plasma can expand access to investigational antibody-based therapies during public-health emergencies.

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